The Illinois Department of Human Services, Division of Substance Use Prevention and Recovery (IDHS/SUPR) aims to address the overdose crisis by reducing the number of opioid overdoses through the expansion of community-based Overdose Education and Naloxone Distribution (OEND). IDHS/SUPR manages the Drug Overdose Prevention Program (DOPP). Individuals and organizations can distribute naloxone, the antidote to opioid overdose, in their communities in Illinois by registering as an OEND program with DOPP. Naloxone has been successfully distributed and used by people who use opioids, including heroin, or who may have an Opioid Use Disorder, their family and friends, and professionals working in substance use treatment programs, social service agencies, hospitals, law enforcement, and public health departments. IDHS/SUPR provides 1) training and technical assistance for DOPP-enrolled OEND programs and 2) support with identifying paths to acquire naloxone. DOPP-enrolled OEND programs are responsible for developing training materials, maintaining a supply of naloxone, and establishing sites to train their community members on how to administer naloxone. These OEND programs are essential to ending the overdose crisis in Illinois by making sure that anybody who may witness an opioid overdose is equipped with naloxone and the knowledge they need to save a life.