8.9 Identification of Estrogen-exposed Offspring

Part II: Guidelines for Client Services and Clinic Management


Children of women who received diethylstilbestrol (DES) or similar hormones during pregnancy may have abnormalities of their reproductive systems or other fertility related risks. Women born between 1940 and 1970 must be asked if their mothers took estrogens during pregnancy. Clients with prenatal exposure to exogenous estrogens must receive information/education and special screening either on site or by referral.

Suggested approaches for identifying and treating estrogen-exposed offspring include:

  • History includes screening questions for in-utero exposure to estrogen.
  • Counseling for female clients who had prenatal exposure to DES should include information about the risks of developing a rare cervico-vaginal tumor and pregnancy complications. A referral for colposcopy should be made.
  • Counseling for male clients who were exposed should include information that they are at risk of certain lesions of the genital tract and for decreased fertility.

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